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Advantages of In-House Generation of Nitrogen for HPLC with ELSD

Evaporative light scattering detection (ELSD) is a universal detection technique for HPLC that provides a number of distinct advantages over other commonly employed detection methods such as UV-VIS absorbance, fluorescence, and electrochemical measurements. The technique allows for the trace-level detection of essentially all compounds in the sample and does not require the presence of a chromophoric group for detection (required for UV-VIS absorption or fluorescence detection) or an electroactive group (required for electrochemical methods such as coulometry). While other universal techniques for HPLC exist (e.g., refractive index measurements), they provide poor sensitivity and are generally restricted to isocratic elution.